He had gone through relapses and multiple chemotherapy regimens and was planned for a matched unrelated donor
Despite more precise human leukocyte antigen (HLA) typing, effective methods to prevent graft rejection and/or reduce the incidence and severity of acute GVHD, infection remains a common cause of transplant failure in patients receiving an allograft from a matched sibling or a matched unrelated donor
Moderate to severe GvHD (with grade II being moderate and grade III-IV GvHD being severe) occurs in 30-50 percent of matched related hematopoietic stem cell transplants (HSCT) and 50-70 percent of matched unrelated donor
recipients, as shown in the literature describing historical clinical experience.
Moderate to severe GVHD Grades II-IV occurs in 30-50 percent of matched related hematopoietic stem cell transplants (HSCT) and 50-70 percent of matched unrelated donor
But infections that occurred after 30 days, primarily aspergillosis, candidiasis, and adenovirus, were far more common in children who received unrelated cord blood and matched unrelated donor
transplants than in children who received autologous or matched or partially-matched sibling transplants.