This report fully validated the two main conclusions drawn from my 2004 study: (1) respiratory-to-fermentative shift as the mitochondrial dysfunction in inflammatory-immune disorders; and (2) succinate retention as the Krebs cycle
dysfunction of highest clinical interest.
The Krebs cycle
is the metabolic pathway that takes carbohydrates, proteins, and fats and converts them into carbon dioxide and water to generate a usable form of energy for the body.
Taking part in structured drill sessions and sprint training in the pool allows you to work at your "anaerobic" capacity which increases stamina and also improves the Krebs cycle
The concepts of glycolysis, Krebs cycle
, and the electron transfer chain are abstract with multiple steps that are difficult to follow.
Pyruvate, which is produced by the digestion of sugars, is the compound that starts the Krebs cycle
- the complex series of chemical reactions in cells that releases energy as part of respiration.
The resultant high concentrations of acetyl-CoA and acetoacetyl CoA would depress the level of ACAT and generate more [beta]-hydroxybutyric acid; high concentrations of acetyl-CoA would also accelerate the Krebs Cycle
and produce more ATP, which is stored as phosphocreatine, as a consequence of increased expression of creatine kinase.
The Krebs cycle
, the pathway (through which) carbs, fats, and proteins are supposed to be broken down, gets backed up and doesn't flow like it's supposed to," Ms.
3NP has long been known to inhibit succinate dehydrogenase activity of the Krebs cycle
and the respiratory chain in mitochondria.
The evolving metabolomic tools that allow us to simultaneous study multiple metabolic pathways have been used mainly in targeted studies of candidate alternate pathways such as studies of the involvement of the Krebs cycle
in PA and MMA.
For example, the vitamin B complex--thiamine, riboflavin and niacin--has a critical role in the Krebs cycle
via which the required energy is generated.