Using data from 153 brain samples from individuals of European ancestry, they discovered that the mutations to FTO introns
that affected body weight are associated with IRX3 expression, but not FTO.
We demonstrated that the first intron
of the porcine [beta]-casein gene contains a transcriptional promoter/enhancer sequence and that lactogenic expression of the porcine [beta]-casein gene was probably regulated by the first intron
Evolutionarily conserved genes preferentially accumulate introns
Specifically, we determined various aspects of introns
particularly the length, number and relationship to CpG islands across different taxa, etc.
show often moderate to high levels of length polymorphisms, and levels of nucleotide variability that are usually higher than in exons, which are more constrained.
are widely viewed as having evolved from self-splicing group II introns
The parallels between introns
and inteins extend even further.
But we saw the RNA molecule flexing on its own, with the intron
folding and unfolding in a way that brings the exons closer together, suggesting a more active role for introns
," Nature quoted Walter as saying.
Analyses of the intron
4 variable number of tandem repeats (VNTR) polymorphism, the E298A polymorphism in exon 7, and the G10-T polymorphism in intron
23 of the ecNOS gene were performed as we have previously described (15).
A single genetic change could not have shortened all chicken introns
, the researchers argue.
and exons play a central role in those instructions, providing the basis for our new name.
Because sequence data for DRB introns
are limited, the possibility of failed amplification because of primer mismatch adds a degree of uncertainty that both DRB1* alleles have been amplified.
That year, two research groups showed that the DNA instructions for a single protein may frequently be interrupted by introns
, fragments of DNA that serve no apparent purpose.
By cloning and manipulating the gene from the yeast Rhodotorule glutinis and deleting all the non-coding introns
, CAMR have developed a way of producing the phenylalanine ammonia lyase in high quantities in bacteria, as well as in yeast", Dr.
Using a chemical probe, two chemists at the California Institute of Technology in Pasadena have discovered a structural landmark that appears to flag introns