These data suggest that linoleic acid from the fruits of Vitex agnus-castus can bind to estrogen receptors and induce certain estrogen inducible genes
Ridgefield, CT) has patented a method of therapeutic induction of apoptosis in activated inflammatory cells, or cells at a site of inflammation, which involves introducing into those cells a chimeric gene containing an apoptosis-inducing gene (AIG) driven by a promoter of an inducible gene
activated in inflammation and a promoter enhancer such that the inflammatory cells are targeted.
SEATTLE -- Today, Kineta scientists will present new findings from the company's antiviral drug development program - vaccine adjuvants of the Retinoic Acid Inducible Gene
I (RIG-I), at the Fifth Annual International Society for Vaccines, Global Congress, in Seattle.
The company is developing synthetic ligands of a novel receptor of the innate immune system, Retinoic acid Inducible Gene
I (RIG-I), which recognizes viral RNA.
Molecular basis for effects of carcinogenic heavy metals on inducible gene
Kineta's program, Agonists of the Retinoic Acid Inducible Gene
I (RIG-I) Innate Immune Pathway, focuses on targeting RNA viruses including: hepatitis C, influenza, West Nile virus, respiratory syncytial virus (RSV), Dengue fever and the common cold.
Key products include high-performance qPCR and PCR reagents (including the Ex Taq[TM], LA Taq[TM], Titanium([R]), and Advantage([R]) enzymes); RT enzymes and SMART[TM] library construction kits; the innovative In-Fusion([R]) cloning system; Tet-based inducible gene
expression systems; and a range of Macherey-Nagel nucleic acid purification tools.
Under the terms of the five year contract, Kineta will identify, analyze and initiate preclinical studies on small molecules that activate the retinoic acid inducible gene
I (RIG-I) pathway of the innate immune response.