IRF6 plays an important role in initiating cellular interferon-stimulated gene-mediated antiviral responses and in the transforming growth factor-p signaling pathway.
Genomic, cDNA and embryonic expression analysis of zebrafish IRF6, the gene mutated in the human oral clefting disorders Van der Woude and popliteal pterygium syndromes.
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes.
Two missense mutations of the IRF6 gene in two Japanese families with popliteal pterygium syndrome.
Two novel mutations affecting splicing in the IRF6 gene associated with van der Woude syndrome.