In hypertrophic scars
and keloids, asiaticoside may increase the expression of matrix metalloproteinase-1 (MMP-1), and this may induce an intermediate state of cell adhesiveness (cellular "de-adhesiveness") that may be involved in tissue adaptation and repair (Murphy-Ullrich 2001; Lu et al.
In November 2013, the Company started its first Phase 2a study (RXI-109-1301) in patients who had pre-existing hypertrophic scars
present on their lower abdomen for at least one year.
Because animal models do not exist - only humans develop hypertrophic scars
- there have been difficulties in gaining an understanding of such wounds.
RXi Pharmaceuticals Corporation (OTC: RXII), a biotechnology company focused on discovering, developing and commercializing innovative therapies addressing major unmet medical needs using RNA-targeted technologies, today announced that its second Phase 1 study with their anti-scarring drug, RXI-109, for the management of surgical and hypertrophic scars
and keloids, has been fully enrolled.
Endo has also discussed the potential expansion of its CCH development pipeline into currently un-licensed assets including uterine fibroids, human lipoma, capsular contracture of the breast, Dercum's disease, knee arthrofibrosis, urethral strictures, hypertrophic scars
Upon examination in the senior author's practice, the patient exhibited two large, vertically oriented hypertrophic scars
EXC 001 or placebo was administered intradermally in 21 subjects who were undergoing elective revision of hypertrophic scars
of the breast.
True (A) or false (B)--fill in only block A or B: Corticosteroid injections are used as first-line therapy for hypertrophic scars
PARIS -- In high-risk patients, the prophylactic use of silicone gel sheeting immediately after surgery reduces by nearly half the chances of hypertrophic scars
and keloids developing afterward, Dr.
are raised above the surrounding skin and are thick, red, and frequently itch.
This technology has been incorporated into the cup sections of a brassiere to reduce the potential for hypertrophic scars
and keloids after breast surgery, according to Bio Med Sciences, 1111 Hamilton St.
We are very pleased with the outcome of the 3-month evaluation of our ongoing Phase 2a study with RXI-109 for the treatment of hypertrophic scars
following scar revision surgery," said Dr.
These medical-grade siliconebased products are designed to improve the appearance of keloids and hypertrophic scars
resulting from surgery or trauma to the skin.
rather frighteningly go on thickening for up to six months and may be itchy or painful.