41) Specifically, in cells with BAX overexpression, BAX/BAX homodimers
predominated, and turning the cells susceptible to induced apoptosis.
Many antioxidant enzymes form homodimers
or homotetramers after transcriptional induction, further increasing signal amplification along the feedback loop (Zhang et al.
or heterodimers of the TGF-AY family ligands bind to and activate a pair of receptors and then phosphorylate the intracellular R-SMADs.
These pro inflammatory cytokines are a group of homodimers
, each made of two 15 KD polypeptide chains joined together by disulfide bonds.
FPP synthases have been identified from several insects and are typically active as homodimers
Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
This approach usually results in efficient production of stable, secreted homodimers
that retain their specificity as assessed in a number of assays.
39) recently proposed that sRAGE might not only function as a 'decoy' to exert its inhibitory effects on RAGE but also act in a more direct way by binding to the cell surface of RAGE to block the formation of homodimers
In addition, the extracellular portion of CD4 could form homodimers
to enhance immune response (Maekawa et al.
Among their topics are early-stage and late-stage intermediate folding, structural information involved in interpreting the stepwise protein folding process, using the "fuzzy oil drop" model to identify the complexation area in protein homodimers
, misfolded proteins, and other selected ab initio methods for predicting protein structure.
UVR also causes dendritic cells and macrophages to secrete immune-suppressive IL-12p40 homodimers
Various isoforms exist in addition to the main 22-kD isoform, and heterodimers, homodimers
, and multimers also occur (3).
Using the BACTH system it was found that both Rv2626 and Rv2625 proteins interact with themselves to form homodimers
Each receptor is activated by binding FGF and heparin, resulting in the formation of FGFR homodimers
and their subsequent activation via autophosphorylation (Mohammadi et al.
As mentioned, it is uncertain whether the pathways for tissue-protection are activated by EPOR homodimers
or heterodimers, both, or another receptor conformation (18).