For histopathological analysis, liver specimens fixed in 10% neutral-buffered formalin were embedded in paraffin, sliced at 5-[micro]m thickness, and stained with hematoxylin and eosin to evaluate the degree of hepatic steatosis
Increased hepatic steatosis
and insulin resistance in mice lacking hepatic androgen receptor.
MRI is very useful for making the diagnosis of focal hepatic steatosis
, which appears isointense or hyperintense to liver on in-phase images (Figure 4A) and loses signal on out of-phase images (Figure 4B).
In the ad libitum study, monkeys fed the high-fructose diet developed hepatic steatosis
in comparison with the control diet, and the extent of hepatic fat accumulation was related to the duration of feeding.
Next, to elucidate the mechanisms of HBCD-induced hepatic steatosis
in HFD-fed mice, we examined expression of lipid metabolism-related genes in the liver (Figure 1G).
Ultrasound examination of her abdomen showed increased hepatic echogenicity consistent with hepatic steatosis
as well as renal cortical thinning consistent with medical renal disease.
Administration of recombinant FGF-21 lowered plasma glucose and insulin levels, reduced hepatic and circulating triglycerides and cholesterol levels, and improved insulin sensitivity, energy expenditure, hepatic steatosis
and obesity in a range of insulin-resistant animal models.
Kral et al (9) demonstrated that abdominal distribution of fat was a predictor of hepatic steatosis
, independent of body weight or body fat.
Recent studies also have shown that liver-specific knockout of the gene encoding HDAC3 in mice leads to severe hepatic steatosis
and increased expression of lipogenic genes, although whether HDAC3 expression or function is altered by ethanol has yet to be elucidated (Sun et al.
is a risk factor for postoperative complications after major hepatectomy: a matched case-control study.
Nonalcoholic fatty liver disease (NAFLD) implies hepatic steatosis
documented by biopsy or imaging without evidence of a secondary cause.
Key words: Diabetes mellitus, hepatomegaly, transaminase elevation, hepatic glycogenosis, hepatic steatosis
Class-related, serious and common adverse effects of frequently used antiretrovirals Class AEs Serious AEs Nucleos(t)ide reverse transcriptase inhibitors (NRTI) Tenofovir Hyperlactataemia and Renal failure, (TDF) lactic acidosis, with Fanconi's syndrome hepatic steatosis
Lamivudine Lipodystrophic changes (3TC) and emtricitabine (FTC) Zidovudine Anaemia, leuco-or (AZT) neutropenia Abacavir (ABC) Drug hypersensitivity reaction Stavudine(d4T) Didanosine Pancreatitis (ddI) Non-nucleoside reverse transcriptase inhibitors (NNRTI) Efavirenz Drug hypersensitivity Rare (0.
Hypertriglyceridemia, being associated with hepatic steatosis
and oversecretion of large triglyceride-rich VLDL, is central to the pathophysiology of dyslipoproteinemia in type 2 diabetes (7).
Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis