(devil's claw) has a long history of use in traditional Western herbalism for arthritis treatment and an established safety record.
The re-analysis included 7 studies on the effects of Harpagophytum procumbens
, 3 on a Salix extract and one of capsaicin.
Effect of the major glycosides of Harpagophytum procumbens
(Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro.
The results for median percentage change from baseline of Arhus pain, disability and physical impairment were extracted from our seven studies of the possible utility of aqueous extracts of Harpagophytum procumbens
for chronic back pain (2 randomised, double-blind, placebo-controlled studies (Chrubasik et al.
The following plant extracts have been tested: Gentiana lutea, Harpagophytum procumbens
, Boswellia serrata (dry extracts), Usnea barbata, Rosmarinus officinalis and Salvia officinalis (supercritical carbon dioxide C[O.
The quality of clinical trials with Harpagophytum procumbens
Adequate doses of some preparations derived from Harpagophytum procumbens
may be sufficiently effective and safe to be useful for treating low back (Gagnier et al.
For more than 50 years preparations of Harpagophytum procumbens
DC have been used in Europe for the treatment of rheumatic entities (Anonymus, 2003).
This study was carried out to evaluate whether the anti-inflammatory response in rats to the whole extract of Harpagophytum procumbens
is a consequence of adrenal corticosteroid release.
Our examination of the 20 available clinical studies with various preparations from Harpagophytum procumbens
(Chrubasik et al.
Special extracts from the roots of Harpagophytum procumbens
(Devil's Claw) are used in the supportive treatment of inflammatory diseases, and the iridoid derivative harpagoside is thought to be the active principle.
Another interesting finding is that of promising antiplasmodial activity of crude preparations of Harpagophytum procumbens
(Clarkson et al.
Key words: Clinical trials, Harpagophytum procumbens
, internal validity, quality of evidence
The book also contains five chapters on the pharmacology, pharmacokinetics, efficacy and safety of devil's claw, Harpagophytum procumbens
The ESCOP (European Scientific Cooperative on Phy-totherapy 1996) monograph on Harpagophytum procumbens
recommends preparations from its secondary tubers for treating painful arthrosis or tendinitis.