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  • noun

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a focal growth that resembles a neoplasm but results from faulty development in an organ

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Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder characterised by seizures, cutaneous lesions and hamartomatous lesions in various organs (1).
Germ line mutations in the SMAD4 gene have been shown to be associated with juvenile polyposis, an autosomal dominant syndrome predisposing to hamartomatous polyps and colorectal carcinoma.
Subsequent endoscopy demonstrated hundreds of benign hamartomatous polyps throughout the gastrointestinal tract as well as glycogenated acanthosis of the esophagus.
Table 1 Types of polyps found in the colon Types Malignant ** Neoplastic * (10 percent of all polyps) [] Adenomas Yes [] Adenocarcinoma Malignant ** Non-neoplastic (90 percent of all polyps) [] Hyperplastic No [] Inflammatory No (Pseudopolyps) [] Hamartomatous No [] Lymphoid No Types Potential associations Neoplastic * (10 percent of all polyps) [] Adenomas Adenocarcinoma [] Adenocarcinoma Non-neoplastic (90 percent of all polyps) [] Hyperplastic More common in patients in their 50's and 60's [] Inflammatory Inflammatory bowel disease (Pseudopolyps) [] Hamartomatous Inherited polyposis syndromes [] Lymphoid Often an incidental finding * Neoplastic: Abnormal growth of tissue which may be cancerous.
Peutz-Jeghers Syndrome (PJS) is an autosomal dominant genetic condition in which hamartomatous polyps (a benign, noncancerous form) develop in the gastrointestinal tract, including the stomach, small intestine and colon.
Angiomyolipomas (AML) are benign hamartomatous lesions composed of vessels, smooth muscle, and adipose tissue.
Fatal chylopericardium caused by hamartomatous lymphangiomatosis: case report and review of the literature.
Although the combined elements seen in our lesion may raise the possibility of a hamartomatous entity, the lack of a mesenchymal component would argue against that suggestion.
3,4) The etiology of Castleman disease is unclear, but it is believed to be inflammatory or hamartomatous in nature.
Biopsy of colonic polyps revealed cystic dilatation of crypts with oedema of the lamina propria suggesting hamartomatous polyps.
It is now believed to be a part of generalised hamartomatous disorder featuring fat in the soft tissues and even in the bowel, known as Proteus syndrome.
Diagnostic criteria for tuberous sclerosis complex (a,b) Major Features Minor Features Facial angiofibromas or forehead Multiple random pits in dental enamel plaque Ungual or periungual fibroma Hamartomatous rectal polyps More than three hypomelanotic Bone cysts macules Shagreen patch Cerebral white matter radial migration lines Multiple retinal nodular Gingival fibromas hamartomas Cortical tuberous lesion Nonrenal hamartoma Subependymal nodule Retinal achromic patch Subependymal giant cell "Confetti" skin lesions astrocytoma Cardiac rhabdomyoma(s) Multiple renal cysts Lymphangioleiomyomatosis Renal angiomyolipoma (a) Diagnosis (based on Rbach ES, Gomez MR, Northrup H.
Cowden syndrome is characterized by multiple hamartomatous neoplasms of the skin, mucosa, CNS, GI tract, eyes, and genitourinary system.
While their etiology has not been definitively established, isolated hepatic cysts are hypothesized to be hamartomatous tissue.
It is characterized by the presence of hamartomatous (juvenile) polyps that vary in number from five to several hundred (1, 2).