The strong influence of ongoing exposure and loss of body weight on half-life estimates from incident cohorts that were measured decades after the exposure incident is demonstrated by the observation of very long and even negative apparent half-lives
reported for pentachlorodibenzofuran in Yusho patients (Matsumoto et al.
The authors of the paper concluded that monoclonal antibodies with longer serum half-lives
may be of significant benefit to patients undergoing long-term antibody therapy, due to reduced frequency of administration.
2006) were found to have serum elimination half-lives
of PFOA in the same range as monkeys.
In contrast, most studies in the literature that present CSTD-based half-lives
have been assembled retrospectively.
To determine whether improved affinity to the neonatal Fc receptor (FcRn) can result in enhanced therapeutic efficacy, Xencor researchers tested whether antibodies with half-lives
extended up to five-fold in human FcRn transgenic mice and three-fold in cynomolgus monkeys retain efficacy at longer dosing intervals.
In papers being presented today and tomorrow at the American Society for Clinical Pharmacology and Therapeutics meeting in New Orleans, PDL scientists said that three of PDL's humanized antibodies, the SMART(TM) Anti-Herpes Antibody, the SMART M195 Antibody for myeloid leukemia, and the SMART ABL 364 Antibody for tumors of the lung, colon and breast, each demonstrated serum half-lives
of at least two weeks in separate studies in Rhesus monkeys.
Therapeutic proteins; strategies to modulate their plasma half-lives
of DCD for the 10kg and 20kg treatments (0-10cm soil depth) were not significantly different from each other for the applications made in three different seasons.
The time lapse between the peak in emissions and sample collection for biomonitoring is the most influential factor controlling the shape of concentration age trends for chemicals with human metabolic half-lives
longer than 1 year.
allows for reduced dosing frequency, lower dosing, and potentially improved tolerability and efficacy.
are constant, we thought time was sped up inside a buckyball.
As part of Domantis' Albutherapeutics franchise, we are using the AlbudAb approach to further expand our extensive pipeline of proprietary products, both by improving existing drugs and by creating a range of entirely new drugs with exceptional half-lives
So it may be that at least some of the nucleosides are essential in maintaining long-term suppression after you stop the medications, in a way that is perhaps beyond half-lives
The overall half-life is determined--in the case of some of these agents by active metabolites that have lengthy half-lives
, which in turn, can be associated with long-lasting daytime sedation.
On the x-axis, plot the number of half-lives
, and on the y-axis, undecayed atoms.