The baboons were serologically negative, and the 1 baboon examined histologically had mild focal lobular hepatitis, and HBcAg
was detected in liver tissue by immunohistochemical staining.
is a marker of the infectious viral material and it is the most accurate index of viral replication.
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In this study, Inovio developed a synthetic DNA vaccine which is encoded for the HBcAg
antigen and represents a consensus of the unique HBcAg
DNA sequences of all major HBV genotypes (A through E).
The immunological data have demonstrated that all subjects mounted a T-cell proliferative response to both the HBcAg
and to groups of peptides representing the whole sequence of HBcAg
, indicating that the antigen had been successfully delivered to the immune system in all subjects.