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Related to H1 antihistamine: H1 receptor antagonist, Antihistaminergic
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ASTERIA II was a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety profile of omalizumab compared with placebo in 323 patients 12 to 75 years of age with moderate to severe CIU who were receiving H1 antihistamine therapy at approved doses.
Levocetrizine, a highly selective H1 antihistamine, which has additional benefits of nasal decongestion, improving nasal airflow and is cost effective.
While all the nonresponders continued to remain unresponsive during this follow-up period with the regular need for H1 antihistamines, relapse was seen in 7 (15.
7%) Laboratory Eosinophil count /[mu]L Median 170 (25th-75th percentile) (80-320) Basophil number/[mu]L Median 20 (25th-75th percentile) (20-40) Serum total IgE (FJ/mL) Median 71 (25th-75th percentile) (22-167) H1-AH: H1 antihistamines Table 2.
According to the International EAACI/GA2LEN/EDF/WAO guidelines for the management of CSU, updated in 2013 and published in 2014, second generation H1 antihistamines are recommended first-line treatment for CSU.