Its superior sensitivity and specificity reduces the rate of false positive results often associated with traditional guaiac test
The advantages of FIT over the traditional Fecal Occult blood Guaiac test
are as follows: improved patient acceptance so patients adhere to screening which is in part due to the improved collection device, fewer samples collected and no dietary restrictions, and improved specificity; not affected by anticoagulant or non steroidal medications.
Subjects were excluded for the following reasons: positive guaiac test
within 6 months; iron-deficiency anemia within 6 months; rectal bleeding or hematochezia within 12 months; unintentional weight loss of more than 10 pounds within 12 months; optical colonoscopy in previous 10 years; barium enema in previous 5 years; history of adenomatous polyps, colorectal cancer, or inflammatory bowel disease; history of familial adenomatous polyposis or hereditary nonpolyposis cancer syndromes; rejection for optical colonoscopy for any reason; medical condition that precluded the use of sodium phosphate preparation; pregnancy.
Not only was the brush sampling technique (InSure, by Enterix) significantly more sensitive than the guaiac test
(Hemoccult II Sensa, by Beckman Coulter Inc.
Prior to 2006, Kaiser Permanente used several different screening methods, including colonoscopy, sigmoidoscopy and guaiac test
kits, and was finding less than 50 percent participation from their eligible patients.