In a study including 64 newborns of women with one or more of the following pregnancy complications: pre eclampsia, placental abruption and intrauterine growth retardation
, the maternal and neonatal blood was screened for heritable thrombophilic mutations.
Detailed analyses of several molecular regulators yielded data consistent with the hypothesis that alcohol- induced fetal growth retardation
occurs, for the most part, as a result of impaired placental development and transport of nutrients resulting primarily from disruption of the maternal GH-IGF system (Shankar et al.
We evaluated this outcome only among term births to separate children with true growth retardation
from babies that are small because of birth at a young gestational age.
hazard to children and is associated with behavioral problems, learning disabilities, hearing problems and growth retardation
The study found no significant differences by race or ethnicity in a number of other factors including proteinuria, eclampsia, intrauterine fetal distress, intrauterine growth retardation
, abruption, and recurrent preeclampsia.
A developing fetus, deprived of adequate oxygen, suffers intrauterine growth retardation
and subsequent low birth weight.
Prior to treatment, the patient had extremely high insulin levels (5490uU/mL), severe growth retardation
3% of subsequent pregnancies, whereas 12% (24) had hypertension without proteinuria, 14% (28) had intrauterine growth retardation
(IUGR), and 1% (2) had placental abruption.
In general, exposure of marine mammals to persistent chlorinated hydrocarbon contaminants and their metabolites has been implicated as a causative factor in sterility, growth retardation
, perturbation of immunologic function, and reproductive abnormalities.
Among those human cancers studied, mice bearing human lung tumour xenografts appeared most sensitive showing notable growth retardation
and tissue necrosis relative to controls.
Potential applications include treatment for growth retardation
in children and cachexia associated with chronic disease such as AIDS and cancer.
The etiology of intrauterine growth retardation
in babies with congenital heart defects remains unclear.
Severe zinc deficiency causes growth retardation
, diarrhea, skin lesions, loss of appetite and hair loss.
, increased fetal motility, or accelerated fetal bone maturation also can be signs of fetal hyperthyroidism.
2 mg/kg produced a slight delay in tumor growth, while significant growth retardation
was seen at a dose of 6.