Treatment of primary cultured cerebellar granule cells
with 20 [micro]M obovatol could significantly increase the [GABA.
2] entry in rat cerebellar granule cells
following ill vitro exposure to methyl mercury.
Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells
within the dentate gyrus of the hippocampus do not begin forming until midgestation, peaking during the third trimester (in humans, or its equivalent in other organisms) (Bayer 1980).
Moreover, we found that the aqueous extract of KBG protected against glutamate-induced neuronal death (unpublished observation), and reported that the aqueous extract of Cinnamomi Cortex has protective effect against glutamate-induced neuronal death in cultured cerebellar granule cells
(CGCs) (Shimada et al.
This exposure also leads to atrophy that is characterized by specific targeting of glutaminergic and GABAergic precursor cells of the cerebellum (especially granule cells
) resulting in misalignment of Purkinje cells and ectopic and multinucleated granule cells
The PRKCB1 gene is expressed in the granule cells
within the cerebellum (a region of the brain) where the PRKCB1 protein plays a central role in the transmission of signals by the granule cells
to the Purkinje cells.
Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells
is entitled "Selective vulnerability of dentate granule cells
prior to amyloid deposition in PDAPP mice: Digital morphometric analyses" and is also available in the online edition of PNAS at http://www.
In the study, Scheiffele's group demonstrated that these mossy fiber inputs often connect with Purkinje neurons during early brain development, in addition to granule cells
Lhermitte-Duclos disease is caused by hypertrophy (enlargement) of the granule cells
in the cerebellum, which results in headaches, movement disorders, tremor and other problems.
For example, migration of cerebellar granule cells
is affected by TH acting on TR[alpha] whereas development of the cerebellar Purkinje cells is dependent upon TH acting on both TR[alpha] and TP[beta] (Morte et al.
Jude Children's Research Hospital focused on a small region of the hippocampus known as the dentate gyrus, a brain structure needed for memory and learning that is home to the subgranular zone where the neural stem cells destined to become granule cells
Neonatal hypothyroidism also reduces the number of dentate gyrus granule cells
(46) and impairs their dendritic arborization (42,47).
They observed that the loss of Disc1 resulted in hindered migration of dentate gyrus granule cells
to their proper location in the brain.