cell's thin wall crumbles in the alcohol wash and releases the dye.
Ceftazidime-avibactam is an investigational antibiotic being developed to treat serious Gram-negative
On physical exam, both patients had maceration of the toe-webs with a hyperkeratotic rim, a finding noted in other reports of gram-negative
bacteria that are highly resistant to existing treatments include E.
Recently, pan-drug resistant (PDR) and even so-called extensively drug resistant (XDR) Gram-negative
bacteria have started to appear, taking the treatment situation to a critical point.
bacteria are a class of pathogens that includes drug-resistant varieties of bacteria that cause pneumonia, sepsis and other deadly diseases.
Klebsiella and other gram-negative
bacteria are notorious for their ability to produce beta-lactamases, which are enzymes that render penicillin and some other antibiotics useless.
So Melander, Worthington and graduate students Cynthia Bunders and Catherine Reed set to work on a variety of the compound that might prove similarly effective against their Gram-negative
Aztreonam was discontinued if gram-negative
pathogens were not identified or suspected.
The compounds of the first series (lead compound, NAB739) are directly antibacterial against polymyxin-susceptible Gram-negative
enteric bacteria such as Escherichia coli, Klebsiella spp, and Enterobacter spp.
According to the agency, the resistance of gram-negative
bacteria is increasing.
Extensive in vitro data presented reaffirm the enhanced broad-spectrum of activity including Gram-negative
Comparable studies on multidrug-resistant gram-negative
infections have not been performed, to our knowledge.
It exerts strong antibacterial effects against gram-positive and gram-negative
bacteria, aerobes, anaerobes as well as Pseudomonas aeruginosa.
The supply of weapons against multidrug-resistant gram-negative
pathogens is running low, Henry M.