EM studies were revealed that the hyperglycemia (in diabetic rats) in high oxygen environments induced hypertrophy of endoplasmic reticulum and golgi complex
, increased free ribosomes, degranulation and the margination of secretory granules in the beta cells (Hamaguchi et al.
Fatal outcome due to deficiency of subunit 6 of the conserved oligomeric Golgi complex
leading to a new type of congenital disorders of glycosylation.
Each primary and secondary oogonia had a large nucleus with chromatin, a few mitochondria, and the Golgi complex
appeared in the cytoplasm (Fig.
In our patient, the neoplastic ceils exhibited an abundance of dilated PER, a prominent Golgi complex
, a focal presence of microfilament, and mild nuclear indentation.
In the pituitaries from control rats at all time points after DEN administration, most of the granular cells were of the storage type, characterized by many secretory granules and an inactive appearance, with poor development of endoplasmic reticula (ER) and Golgi complex
(Figure 1), as described in detail by others (13,37).
Ultrastructural examination of case 1 at low magnification showed spindle to oval-shaped cells that contained abundant, well-developed rough endoplasmic reticulum and Golgi complex
Several studies with antibodies that bind to the presenilins have indicated that they reside in the endoplasmic reticulum (ER), where the cell synthesizes proteins, and in the Golgi complex
, where proteins are often modified.
The reference text offers cell biologists discussion of topics such as the architecture of the mammalian Golgi, Golgi glycosylation and human inherited diseases, a critical assessment of models for Golgi traffic, entry and exit mechanisms at the cis-face of the Golgi complex
, COPI budding within the Golgi stack, Golgin coiled-coil proteins, organization of SNAREs in the Golgi stack, protein retention mechanisms, Golgi transport proteins structure, Golgi and related vesicle proteomics, entry at the trans-face of the Golgi, the signaling network, Golgi positioning, Golgi development, Golgi biogenesis, and evolution and diversity of the Golgi.
Poliovirus infection and expression of the poliovirus protein 2B provoke the disassembly of the Golgi complex
, the organelle target for the antipoliovirus drug Ro-090179.
Of the samples from 10 probable CDG-II patients, 1 sample also showed on IEF a cathodal shift of the O-glycosylated apolipoprotein CIII (not shown), and conserved oligomeric Golgi complex
subunit 1 (COG-1) deficiency was later diagnosed in that sample donor (4).