1995) FAS is highly expressed in the germinal center
but is not required for regulation of the B-cell response to antigen.
The residual lymph node showed reactive germinal centers
and tingible body macrophages, but no hemophagocytosis (Figure 1).
The morphologic domain comprises features from 3 categories: (1) high-resolution computed tomography imaging patterns commonly found in patients with CTD-ILD, such as those with NSIP, organizing pneumonia, NSIP with organizing pneumonia, and lymphoid interstitial pneumonia; (2) histopathologic findings in an SLB that are highly associated with the presence of CTD, such as an NSIP pattern, organizing pneumonia pattern, lymphoid interstitial pneumonia pattern, the presence of interstitial lymphoid aggregates with germinal centers
, and diffuse lymphoplasmacytic infiltration with or without lymphoid follicles; and (3) multicompartment involvement, which includes additional features evident on diagnostic imaging, histopathology, cardiac catheterization, or pulmonary function testing.
Hyalinized small blood vessels penetrating follicular germinal centers
are characteristic of HV-CD.
Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center
B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription.
Antibodies to this protein stain the germinal center
cells in lymphoid follicles, follicular cells, and interfollicular cells in follicular lymphoma, large B-cell lymphomas, and Burkitt's lymphoma, and the majority of the Reed-Sternberg cells in nodular lymphocyte-predominant Hodgkin's disease.
Prognostic impact of immunohistochemically defined germinal center
phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy.
A study led by Chen Dong, PhD, professor in MD Anderson's Department of Immunology and director of the Center for Inflammation and Cancer, found an "off-switch" in the germinal center
, where the immune system T cells and B cells interact to produce large quantities of antibodies.
Data from gene expression studies have indicated that markers of germinal center
(GC) derivation are associated with clinical behavior in DLBCL in immunocompetent patients.
CD10, BCL6, and MUM-1 staining patterns were compatible with a tumor of germinal center
origin according to the Hans' algorithm.
Both studies also found that mutations in MEF2B are associated with a form of the cancer called germinal center
Objective: Our aim was to investigate the expression of apoptosis-associated proteins (bc1-2, bcl-xl, bax, bak, bid), apoptotic index (AI) and proliferation index (PI) in germinal center
B-cell-like immunophenotypic profile (GCB) and non-GCB of diffuse large B-cell lymphoma (DLBCL).
Finally, the authors assess certain apoptosis-related proteins, since it has been described that germinal center
B cells with unfavourable or crippling mutations are normally quickly eliminated by apoptosis.
Both 5' noncoding mutations of the bcl-6 proto-oncogene and immunoglobulin variable region gene mutations are found in normal germinal center
cells; their presence in DLCL-B is consistent with a germinal center
or post-germinal center
stage of differentiation.
Biopsy samples of lymphocytoma lesions showed dense nodular lymphocytic infiltrates in the reticular dermis with well-delineated lymphoid follicles, no atypical mitosis, B-lymphocytes (anti-CD20, DAKO, Carpenteria, CA, USA) in the germinal center
(Figure 2, panel A), T-lymphocytes (anti-CD45 RO+) in the follicular zone (Figure 2, panel B), and no CD3+ cells.