KEY WORDS: Bayesian, biomarker, cancer risk, case--control study, chromosomal aberration, genetic polymorphism
, glutathione S-transferase, GSTM1, GSTTl, Monte Carlo Markov Chain.
concomitant drug administration) and by genetic polymorphisms
Moreover, little is known about the effects of genetic polymorphisms
of xenobiotic metabolism on pulmonary function.
Clinical significance of the CYP2D6 genetic polymorphism
These groups include women on antiepileptic drugs or drugs that have antifolate activity, such as sulfonamide and methotrexate; as well as those with some genetic polymorphisms
in the folate cycle.
The first included chapter covers discusses genetic variability in crustaceans, including polychromatism, cytogenetics, and genetic polymorphism
16) indicated that the Arg194Trp genetic polymorphism
may be associated with an increased risk of developing esophageal squamous cell carcinoma (ESCC).
APOE4 carriers account for more than half of Alzheimer's patients and the APOE4 genetic polymorphism
accelerates disease progression and onset of cognitive impairment by seven to nine years per gene copy.
In recent years, the genetic polymorphism
of goat casein has raised considerable research interest because goat casein polymorphisms are related to milk quality, milk composition and technological properties (Martin et al.
35) investigated the genetic polymorphism
of synapsin III in schizophrenia.
And lastly, but more importantly, how far and to what limit genetic polymorphism
can be held responsible for such variations?
The present study conducted on 230 samples (115 each from pesticide exposed and control subjects), was aimed to evaluate the pesticides induced genotoxicity and to correlate genotoxicity with genetic polymorphism
of CYP1A1, CYP3A5, PON1, GSTM1, GSTT1, GSTP1 and NAT2 enzymes coding genes.
Partitioning where a genetic polymorphism
has dominant or recessive effects with attributable variance of 4% or greater would be practical, as illustrated above.
The genetic polymorphism
analyses for the GSTM1 gene was determined by the multiplex polymerase chain reaction (PCR) using the previously described method .
Background & objectives: Mercaptopurine, azathioprine, and thioguanine, used as antineoplastic agents and immunosuppressants are catabolized by thiopurine methyltransferase (TPMT) enzyme, which exhibits genetic polymorphism