Viral vector-mediated gene transfer
in diabetes 122
Over the years, some gene transfer
enthusiasts have advanced extravagant claims about its promise.
Because the TH/bZIP construct used in somatic gene transfer
experiments had proven suitable for detecting of [T.
High rates of gene transfer
are known to be associated with the plant root system and the germinating seed.
In spite of the increasing number of preclinical studies, there have been a limited number of early clinical studies in vascular gene transfer
For example, GTI is working on the development of safe and effective vectors for gene transfer
Immunology of cutaneous gene transfer
To begin to overcome some of the challenges of in vivo assessment of EDC modulation of gene transcription, we have validated polyethylenimine (PEI)-mediated somatic gene transfer
(Lemkine and Demeneix 2001; Ouatas et al.
In this issue, Mark Frankel refers to such interventions as "inheritable genetic modifications," and Nancy King refers to them as "germline gene transfer
" (since it is by making changes to germ cells that gene transfer
Horizontal gene transfer
is the transfer of genetic material between organisms and even species.
Related topics include improvements in vector development, delivery systems, and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease, as well as ethical, legal, and regulatory issues related to the gene transfer
Arnaud and his colleagues decided to look at seeds as well as pollen as vehicles of gene transfer
In this issue of the Report, Nancy King, a lawyer, bioethicist, and former member of the NIH Recombinant DNA Advisory Committee, highlights the broad array of ethical and societal issues raised by the risk of germline gene transfer
of donated gene sequences--that is, the risk that the donated DNA sequences will be passed on to offspring of the recipient, with potential harmful effects.
Arnold Melman, Natan Bar-Chama, Andrew McCullough, Kelvin Davies, and George Christ, from Albert Einstein College of Medicine/Montefiore Medical Center (Bronx, NY), Mount Sinai School of Medicine and New York University School of Medicine (New York, NY), and Wake Forest University School of Medicine (Winston-Salem, NC), reported the results of the first human gene trial in erectile dysfunction, concluding that, "the promising primary safety outcomes of the study and preliminary indications of effectiveness provide evidence that hMaxi-K gene transfer
is a viable approach to the treatment of ED and that further studies investigating the efficacy of hMaxi-K in patients with ED should be performed.
The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer
into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem cells.