3 mg/dL), and gamma glutamyl transferase
(GGT) 97 (reference 12-58).
In addition, patients with fatty liver disease had higher median BMI, ALT level, insulin resistance (based on pre-metformin homeostatic assessment), and gamma glutamyl transferase
level, as well as a lower median fasting HDL cholesterol level, compared with women who did not have fatty liver disease.
Of the 44 patients who enrolled in this study, 32 completed the 48-week treatment period, with only two patients discontinuing participation in the study as a result of adverse events that were considered possibly or probably related to study medication, one following a reversible increase in the level of gamma glutamyl transferase
(GGT), an enzyme associated with the liver and biliary tract, and another following a diagnosis of interstitial nephritis.
Concurrent elevations of serum gamma glutamyl transferase
and serum alanine aminotransferase may indicate overdose.
BG elicited a significant increase in gamma glutamyl transferase
concentrations at 250 mg/kg.