(redirected from Gain-of-function)
Also found in: Dictionary, Medical, Legal, Encyclopedia.
Related to Gain-of-function: conditional mutant
Graphic Thesaurus  🔍
Display ON
Animation ON
  • noun

Synonyms for mutation

Synonyms for mutation

the process or result of making or becoming different

the process or result of changing from one appearance, state, or phase to another

Synonyms for mutation

(biology) an organism that has characteristics resulting from chromosomal alteration

a change or alteration in form or qualities

References in periodicals archive ?
Gain-of-function mutation of c-kit in human gastrointestinal stromal tumors.
The characterization of naturally occurring gain-of-function and loss-of-function human PCSK9 variants has increased our understanding of the cell biology and function of this secreted glycoprotein.
RAS genes are the most common targets for somatic gain-of-function mutations in human cancers.
This suggests that the outcome on cell fitness is determined by the relative contribution of aggregation formation, and its effect: either loss-of-function or gain-of-function.
This study highlights a gain-of-function experiment that occurred in nature and shows us there are avian flu viruses out there beyond H5N1 and H7N9 that could pose a threat to humans," said corresponding author Stacey Schultz-Cherry, Ph.
The first gain-of-function mutation associated with venous thrombosis [the G1691A substitution in the F5 [3] gene, coagulation factor V (proaccelerin, labile factor)] was also found by studying an abnormal plasma phenotype (resistance to activated protein C).
We will then use loss- and gain-of-function strategies to define the individual miRNAs that impact Teff or Treg differentiation and disease pathogenesis; dissect the external cues and intracellular mechanisms that regulate miRNA expression; and identify the mRNA networks controlled by key miRNAs in Teff and Treg differentiation.
1] Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas,Liwei Zhang, Lee H Chen, Hong Wan, Rui Yang, Zhaohui Wang, Jie Feng, Shaohua Yang, Sian Jones, Sizhen Wang, Weixin Zhou, Huishan Zhu, Patrick J Killela, Junting Zhang, Zhen Wu, Guilin Li, Shuyu Hao, Yu Wang, Joseph B Webb, Henry S Friedman, Allan H Friedman, Roger E McLendon, Yiping He, Zachary J Reitman, Darell D Bigner, Hai Yan, Nature Genetics, Advance Online Publication, DOI: 10.
In a presentation titled "Myeloproliferative disease, autoimmunity and cancer in mice with targeted deletion of miR-146a gene" Regulus scientists and collaborators from the California Institute of Technology demonstrated the biological role of miR-146a by establishing loss- and gain-of-function mouse models.
PILS5 gain-of-function reduces canonical auxin signaling (Barbez et al.
Inherited erythromelalgia is caused by gain-of-function mutations in Nav1.
Three loss-of-function alleles (G946A, A1513C, and T1729A) have been characterized in recombinant expression systems, and similar methods have recently been used to characterize a gain-of-function allele (C489T) (20-23).