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GH-RH antagonists represent a potential novel class of promising anti-cancer agents that may offer distinct advantages as compared to other classes of anti-tumor agents, with utility in a variety of tumor types.
The addition of GH-RH antagonists, which may offer broad therapeutic utility as anti-cancer agents and endocrine therapy, represents an important step in our continued effort on building a strategic portfolio in oncology and endocrinology, our current areas of focus," concluded Mr.
GH-RH is a hormone secreted in the brain by the hypothalamus that acts on the pituitary gland to stimulate the synthesis and the release of growth hormone (GH).
Initial, early evidence for the anti-tumor activity of GH-RH antagonists was provided by research conducted at Tulane University, which demonstrated that GH-RH antagonists inhibit the growth of a broad range of cancer cell lines, including pancreatic, colorectal, prostate, breast, renal, small- cell/non small-cell lung cancer, osteosarcoma and glioblastoma.