Despite the many clear scientific advantages we believe MANF possesses over GDNF
, most notably impacting protein folding and modulating toxic calcium levels, the Company had previously been unable to point to a definitive behavioural animal model data to show improved benefit of MANF over GDNF
in the Parkinson's disease indication.
Normal fetal lung (n = 5) showed strong GDNF
expression in both the epithelium of the primitive airways and the vessels (Figure, a).
Thus, rather than using GDNF
itself, Corfas and colleagues created a skin cream containing a small-molecule compound, called XIB4035, which enhances GDNF
Their previous work showed that intranasal delivery of GDNF
protects dopamine neurons from damage by the neurotoxin, 6-hydroxydopamine (6-OHDA), a standard rat model of PD.
No mutations were found in the GDNF
, EDNRB and EDN3 genes (data not shown).
The implanted devices sent a regular flow of GDNF
up a tube to the person's head and into the putamen.
uniQure will continue with AMT's strategy to invest in the hemophilia B, GDNF
and AIP programs, as well as the collaboration with Institut Pasteur on Sanfilippo B, but will not invest significant additional funds into Glybera unless and until it receives a positive decision from regulatory authorities.
Mutations in RET were found in 19% (16 of 84) of the patients, whereas mutations in EDNRB, EDN3, and GDNF
were found in 4, 2, and none of the 84 patients, respectively.
therapy, the monkeys showed measurably improved posture and balance.
MedGenesis' investigation of GDNF
, a biological neurotrophic factor and potential disease-modifying therapy.
This involves moving forward in partnering discussions for several of our gene therapy products, including hemophilia B and GDNF
In a model simulating the progression of human retinal degeneration, the researchers treated mice with nanoparticles carrying a gene for GDNF
(Glial Cell Line-Derived Neurotrophic Factor), a protein known to protect the photoreceptor cells in the eye.
The drug GDNF
, or Glial Derived Neurotrophic Factor, or a placebo is injected via the catheter directly into Sibley's brain once a month.
is one of a family of neurotrophic factors, molecules that maintain and nourish neurons.
AMT is also looking at additional collaborations with academic groups, which would contribute towards the short-term funding of its GDNF
program for up to three indications.