Hippocampal sclerosis in tau-negative frontotemporal lobar degeneration
Victor Villemagne of the Austin Hospital, Melbourne, used florbetaben PET imaging in 26 Alzheimer's patients, 11 with frontotemporal lobar degeneration
(FTLD), 6 with Lewy body dementia (LBD), and 26 healthy controls.
Associated disease groups include Alzheimer disease (AD),  Parkinson disease, Parkinson disease dementia, and frontotemporal lobar degeneration
TAINAN, Taiwan -- A southern Taiwan-based National Cheng Kung University (NCKU) research team has discovered that rapamycin, a drug as a autophagy activator is a possible treatment to alleviating frontotemporal lobar degeneration
(FTLD), one of the mainly causes of dementia, and so far no medication can be used.
WHEREAS, Alzheimer's disease is the 6th leading cause of death in citizens age 65 and older; with a new diagnosis of Alzheimer's disease or a related disorder such as dementia with Lewy bodies, frontotemporal lobar degeneration
, Parkinson's disease, amytropic lateral sclerosis and mixed dementia occurring every 69 seconds in the U.
Pathologic findings in neurodegenerative disorders Important Useful pathologic immunohistochemical Disorder findings stains Alzheimer disease Senile plaques and Ass protein, tau, neurofibrillary ubiquitin tangles Frontotemporal lobar degeneration
(FTLD): Pick disease Pick bodies Tau FTLD with TDP43 Motor neuron TDP43, ubiquitin and ubiquitin disease inclusions inclusions FTLD with parkinsonism Neurofibrillary Tau, ubiquitin linked to tangles chromosome 17-tau Corticobasal Ballooned neurons, Tau degeneration tufted astrocytes, coiled bodies Progressive Globose Tau, ubiquitin supranuclear neurofibrillary palsy tangles Dementia with Cortical Lewy [alpha]- Lewy bodies bodies synuclein, ubiquitin Table 2.