Prior fracture is defined as a previous fragility fracture
after 40 years of age excluding fractures of the face, fingers and toes.
A meta-analysis of more than 45,000 women with information on prior fractures from 11 multinational prospective trials demonstrated that a past history of an adult fragility fracture
increased the risk of any fracture by 84% and subsequent hip fracture by 77% compared with no past history of fragility fractures
A bone fragility fracture
is by definition caused by a minimal injury that would not normally break a bone.
Intermittent teriparatide (PTH) is an anabolic treatment option that is used for women at very high risk of fragility fracture
Unless a therapy has been demonstrated prospectively to reduce the likelihood of fragility fractures
, however, it cannot receive regulatory approval for treatment of osteoporosis.
An analysis adjusted for demographics, comorbid disease, smoking, and alcohol abuse determined that men with HIV had a 24% higher fragility fracture
rate than men without HIV (Table 2).
did not involve the skull, facial bones, fingers, or toes, and were not linked with severe trauma or pathological fractures.
5] Further, a claims-based study carried out in Ontario compared 19 079 men aged at least 66 years with prostate cancer who had used ADT for at least 6 months or who had undergone orchiectomy with matched controls who had not received ADT; the former group had a significantly increased risk of fragility fractures
A number of large studies have demonstrated fracture risk reduction with vitamin D in patients with prevalent fragility fractures
prevalence rose steeply starting at age 40 in both the HIV-positive and negative groups, but the climb was steeper among both women and men with HIV than in their HIV-negative counterparts (Figure 2).
Survival rates following a wrist fracture, the third most common fragility fracture
and the number one upper extremity fracture in older adults, also are lower among men.
celiac or Crohn's disease), previous fragility fracture
, or a family history of osteoporosis and fractures.
A score that predicts death and hospital admission in people with HIV infection also predicted which male Veterans would have a fragility fracture
(a bone broken because of low bone density) during an average 6 years of care.
Finite element analysis of the MR images revealed lower elastic modulus in the femoral neck of the fragility fracture
5 or less at any anatomic site or a T score of -2 or less with one risk factor (fracture or parental hip fracture after age 50, prior hyperthyroidism, inability to rise from a chair with arms elevated, or current smoker) or a T score of--1 or less with a history of a fragility fracture