Two-thirds of women with uncomplicated urinary tract infection treated symptomatically with ibuprofen 400 to 600 mg three times a day for three days recovered without use of antibiotics in three separate randomized clinical studies against ciprofloxacin, mecillinam, and fosfomycin
Antimicrobial susceptibility against polymyxin B, Tigecycline and Fosfomycin
was done by Kirby-Bauer disc diffusion method using disc polymyxin B 300 units, Tigecycline 15ug and Fosfomycin
Non-susceptibility of the isolates for rifampicin, fusidic acid and fosfomycin
was noted for 58(25%).
has historically shown excellent in vitro activity against vancomycin-resistant enterococci, and therefore might be considered as a treatment option for urinary tract infection caused by this organism (4).
Carbapenems, moxalactam, tigecycline, and fosfomycin
maintained excellent in vitro activity against the E.
AMP, ampicillin; TIC, ticarcillin; AMC, amoxicillin-clavulanic acid; PTZ, piperacillin-tazobactam; CF, cephalotin; CFZ, cefazolin; CFX, cefuroxime; FOX, cefoxitin; CTX, cefotaxime; CAZ, ceftazidime; CPM, cefepime; ATM, aztreonam; ERT, ertapenem; GEN, gentamicin; AMI, amikacin; KAN, kanamycin; SXT, trimethoprim-sulfamethoxazole; NAL, nalidixic acid; NOR, norfloxacin; CIP, ciprofloxacin; LEV, levofloxacin; C, chloramphenicol; NIT, nitrofurantoin; TET, tetracycline; DOX, doxycyclin; TGC, tigecycline; PB, polymyxin B; FOS, fosfomycin
Keep in mind that 3- to 5-day courses of antibiotics (nitrofurantoin, trimethoprim-sulfamethoxazole, fosfomycin
, or beta-lactams) for UTIs are as effective as longer courses, and are associated with better compliance and fewer adverse effects, (A)
Adult patients (over 17 years old), symptomatic and who were unresponsive and /or couldn't use prior fosfomycin
, nitrofurontain and/or other antibiotic treatments were included in the study.
There were intermediate zone of inhibition found on claforan, nalidixic acid, amoxycillin, fosfomycin
, fortum, and erythromycin on Mueller Hinton's agar after 24 hours incubation.
has been introduced for the treatment of infections with multidrug-resistant uropathogens for which there are limited treatment options.
Nitrofurantoin and fosfomycin
are noted to have lower resistance levels, namely, 13.
On sensitivity testing by disk diffusion method, the isolated bacteria was sensitive to enrofloxacin, florfenicol, chloramphenicol, ceftiofur, amoxicillin, clindamycin, and fosfomycin
but was resistant to chlortetracycline and doxycycline.
Minimal inhibitory concentrations of Pasteurella multocida was investigated and found highly resistant for spiramycin and fosfomycin
During the symposium, a breakthrough prescription drug called Monurol (generic name is Fosfomycin
trometamol) was introduced.
The following antimicrobial agents were used: gentamicin, fluorquinolones, fosfomycin
, streptomycin and beta-lactamases according to CLSI (1).