saquinavir

(redirected from Fortovase)
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Related to Fortovase: Invirase
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Synonyms for saquinavir

a weak protease inhibitor (trade name Invirase) used in treating HIV

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References in periodicals archive ?
Pls--Agenerase, Crixivan, Kaletra, Viracept, Norvir, Fortovase, Invirase
Fortovase, the soft gelatin capsule formulation of saquinavir (with tenfold greater bioavailability), became available in 1997.
Fortovase and ritonavir should be taken with a large meal; however, indinavir requires a basic environment for absorption and should be taken on an empty stomach (Lacy et al.
Roche announced in April that it would stop malting its nucleoside reverse transcriptase inhibitor Hivid (ddC) and its protease inhibitor Fortovase in 2006.
TABLE: Currently approved medications for treating HIV/AIDS Protease Entry Nukes Non-nukes Inhibitors Inhibitors Combivir Rescriptor Agenerase Fuzeon (Epivir + Retrovir) Emtriva Sustiva Crixivan Epivir Viramune Fortovase Hivid Invirase Retrovir Kaletra Trizivir (Epivir + Lexiva Retrovir + Ziagen) Videx (regular or EC) Norvir Viread Reyataz Zerit Viracept Ziagen
Interestingly, Hoffman-LaRoche is now moving back to the original Invirase formulation of saquinavir (with a new 500-mg tablet) because it is better tolerated than the Fortovase version when the drug is combined with ritonavir.
In a study reported in the Barcelona conference, 33 patients with multiple drug failures were given a combination of only Kaletra and Fortovase (2 protease inhibitors boosted with Norvir) after resistance testing showed the patients were resistant to most nucleoside drugs.
Protease Inhibitors Nucleotide Reverse Agenerase (generic name: amprenavir) Transcriptase Inhibitor Crixivan (indinavir) Viread (tenofovir, PMPA) Fortovase (saquinavir) Kaletra (lopinavir plus ritonavir) Nucleoside Reverse Norvir (ritonavir) Transcriptase Inhibitors Viracept (nelfinavir) Combivir (AZT plus 3TC) Epivir (lamivudine, also Nonnucleoside Reverse known as 3TC) Transcriptase Inhibitors Hivid (zalcitabine, ddC) Rescriptor (delavirdine) Retrovir (zidovudine, AZT) Sustiva (efavirenz) Trizivir (abacavir plus AZT plus 3TC) Viramune (nevirapine) Videx (didanosine, ddl) Zerit (stavudine, d4T) Ziagen (abacavir)