To expedite the development of vaccines against flavivirus infections
(Japanese Encephalitis and Dengue Fever), Bavarian Nordic is currently investigating opportunities to establish a partially-owned Bavarian Nordic company in Southeast Asia with the involvement of local venture capital funding under the leadership of Bavarian Nordic's collaborative partner in Malaysia, Professor Mary Jane Cardosa.
Like most disease associated with flavivirus infection
, WNV infection may be either silent or overt with a range of signs and symptoms.
There are no drug therapies currently to treat any flavivirus infections
In Europe, tick-borne encephalitis (TBE) is one of the most common flavivirus infections
of the central nervous system and is endemic to several countries.
The animals were free from clinical symptoms associated with flavivirus infections
A study in Nigeria determined the prevalence of flavivirus infections
among 1,816 children and adults from urban and rural areas in samples obtained mainly during the early 1970s.
A case report of an adverse reaction to the yellow fever virus vaccine in a person heterozygous for CCR5[DELTA]32 and a link between the CCR5[DELTA]32 allele and severe tickborne encephalitis symptoms suggest that CCR5 may play a role in the immune response to other flavivirus infections
as well (7,8).
In the samples from Yap Island, cross-reactive results in sera from convalescent-phase patients occurred more frequently among patients with evidence of previous flavivirus infections
than among those with apparent primary ZIKV infections (1,2).
Negative control samples included serum samples from healthy persons in areas where dengue is not endemic and from patients with other flavivirus infections
, febrile illness of other causes, or systemic conditions.
The designation "ZIKV probable" was used because secondary flavivirus infections
demonstrate extensive cross-reactivity with other flaviviruses, and in some cases, higher serologic reactivity to the original infecting flavivirus ("original antigenic sin" phenomenon).
We recommend monitoring blood and organ donations for flavivirus infections
IgG-positive results not confirmed by neutralization could be due to cross-reactive antibodies induced by other flavivirus infections
or vaccinations (9,10).
Another possible explanation for the low incidence of WNV disease in Mexico is resistance in the Mexican human population, possibly because cross-protective immunity from other flavivirus infections
such as dengue and St.
A second reason may be the difficulty of making a serologic diagnosis of WNV infection among persons living in geographic regions where several different flaviviruses circulate, and people have multiple flavivirus infections