The monostotic form of fibrous dysplasia
may be an incidental radiographic finding.
While most of us have healthy bones due to drinking milk and receiving ample nutrition from the time of our births, those who suffer from a rare bone disorder called fibrous dysplasia
have bones that can shatter in a split second.
3) These features seen in osteoma are challenging to differentiate from other diseases of bone, including ossifying fibroma, fibrous dysplasia
, and metaplastic ossification.
Review of pathology slides from outside biopsy revealed morphologic features similar to fibrous dysplasia
(Figure 3A); however, on closer inspection at high power, malignant cells with round and spindle nuclei were identified infiltrating irregular bone trabeculae with osteoid formation (Figure 3B).
can be monostotic or polyostotic.
in modern-day humans occurs more frequently than other bone tumors, but Frayer says that, "Evidence for cancer is extremely rare in the human fossil record.
is a benign fibro-osseous lesion, which may present in either monostotic or polyostotic forms.
Incidental lesions typically found in children include unicameral bone cyst, fibrous dysplasia
, and non-ossifying fibroma.
On computed tomography (CT), the ground-glass appearance of fibrous dysplasia
distinguishes it from other lytic lesions (figure 1).
Summary of patients with fibrous dysplasia
(n=25) Sr Age (yr) at Sex Bone Endocrinopathy Cafe-au-lait no presentation involvement macules (poly/mono) 1 11 F P - + 2 24 F P - - 3 30 F P Hyperthyroidism - 4 28 M P Acromegaly - 5 25 M P Acromegaly - 6 40 M P Acromegaly - 7 19 F P Hypophosphatemic + rickets 8 17 F P - - 9 22 F M - - 10 11 M M - + 11 15 M M - - 12 22 F P - - 13 10 M P - - 14 19 F P - - 15 14 F M - - 16 19 F P - - 17 48 M P Acromegaly + 18 38 M M Acromegaly - 19 30 M M - - 20 32 M M - - 21 23 M P - - 22 44 F P - - 23 15 M P - - 24 42 M P - - 25 7 F P Precocious + puberty, hyperthyroidism M, male; F, female; P, polystotic; M, monostotic
More recent studies report that polyostotic fibrous dysplasia
and cafe-au-lait macules are invariably present, while monostotic lesions are less common (3).
In over 50 more articles they explain imagery in such cases as external otitis, exotoses, carcinomas and melanomas, ossicular malformations, meningiomas, metastasis of the middle ear and mastoid, inner ear and petrous bone conditions such as epidermids and petreous apictis, trauma and fractures, the postoperative ear, and such conditions as Paget's Disease, Lymphoma and fibrous dysplasia
Despite extensive fibrous dysplasia
and proptosis, her visual acuity remained intact.
Osseous lesions in the maxilla can represent ossifying fibroma, fibrous dysplasia
, amelogenesis imperfecta, or osteogenesis imperfecta.
Several lesions that can be polyostotic include multiple hereditary exostoses, enchondromas, fibrous dysplasia
and, occasionally, eosinophilic granulomas.