Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke.
53) High-resolution MRI is an excellent tool for visualizing fibrous cap thickness and rupture in plaques.
Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels.
42) Furthermore, the thickness of the fibrous cap overlying an atheroma can be demarcated by OCT.
The fibrous cap of the atherosclerotic plaque separates the luminal clotting cascade from its procoagulant lipid core.
Mechanical factors Increased circumferential stress Vasospasm High turbulent flow Increased liquidity of lipid core Thin fibrous cap Plaque constituents Increased esterified cholesterol Decreased extracellular matrix Increased metalloproteinases Presence of T cells and macrophages Fibrous cap Decreased synthesis of collagen Degradation of collagen Loss of smooth muscle cells Increased presence of cytokines
In addition, any future strategies to combat acute coronary syndromes should target therapeutic modalities that improve endothelial function and strengthen the fibrous cap of atherosclerotic lesions.
The study measured these characteristics in 63 patients, including lipid pools and their thin fibrous caps
that are susceptible to rupture, threatening the vessel and potentially leading to heart attack and death.
Intravascular ultrasound (IVUS) is frequently used to provide direct imaging of the vessel wall, but with resolution in excess of 100 microns, even the best IVUS images are unable to show early stages of intimal thickening, or to identify thin fibrous caps
, a hallmark of plaques believed to be most susceptible to rupture.
The Astato 30 is a high-penetration guide wire specially designed to break through fibrous caps
and calcium deposits, and treat long, complex lesions.