Solar radiation, particularly UVA, is known to penetrate deep into the dermal layer, damaging fibroblasts
, which are the major cellular component of the dermis.
serve as one of the principal mediators in joint destruction by producing proteolytic enzymes, including matrix metalloproteinases (MMPs), via the expression of inflammatory cytokines and chemokines (Mclnnes and Schett 2007).
In this particular case, we've found a way to turn fibroblasts
into 'shapeshifters' nearly on command.
Within the experiment, the conversion method was used to convert fibroblast
cells back into induced neuronal progenitor cells (iNPC) after converting it back to its stem cell stage.
The attachment, proliferation and migration of fibroblasts
in the respective acellular matrices were evaluated and 3-D bioengineered collagen matrices were developed for reconstructive surgery applications.
The goal of this investigation was to further quantify and elucidate the role of fibroblasts
in the fibrous tissue surrounding tricalcium phosphate (TCP) bioceramic implants in context of recent work on macrophage populations and neovascularity.
Fooled into stem cell behavior, the fibroblasts
transformed themselves into stem-cell-like progenitor cells.
produce a plug of fibrous tissue within the clot and new skin tissue forms beneath.
was recently performed a study that evaluate the effect of L-glutamyl L-boroproline (PT-630) on rheumatoid arthritis synovial fibroblasts
(RASFs) and their invasive attitude in joint cartilage of healthy human and in a severe combined immunodeficient (SCID) mouse (1).
They "reprogrammed" scar-forming fibroblast
cells into the building blocks of beating heart muscle by injecting them with a cocktail of five genes.
The article, entitled "Programming Fibroblasts
into Bipotential Hepatic Stem Cells by Defined Factors" is available in the July online Cell Stem Cell journal.
leucotomos on fibroblasts
and melanoma cells may be partly via its cell-specific regulation of TGF-beta expression and partly via its antioxidant property.
Under normal circumstances, fibroblasts
help maintain the structural integrity of connective tissue, and they play a critical role in wound healing and collagen production.
The cells thus derived are called induced pluripotent stem cells (iPSCs) and are typically made from fibroblasts
The Birmingham team have been at the forefront of research investigating the effects of fibroblasts
- types of cell responsible for defining the structure of the lining layer of cells in the joint.