3%), but neither HHV-6 nor HHV-7 DNA was detected in samples from any patients with encephalitis, febrile seizures
, or seizure disorders.
Centers for Disease Control, the study of 86,750 children follows an earlier study published in Pediatrics that showed one particular combination of measles-containing vaccine -- the measles, mumps, rubella and chickenpox containing vaccination (or MMRV) -- was associated with an increased risk of febrile seizures
in 1-to 2-year-old children, compared with same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the V (varicella) vaccine for chicken pox.
Because the risk of febrile seizure
is higher for the quadrivalent (combination) vaccine, providers recommending MMRV should communicate to parents that it increases the risk of fever and febrile seizure
over that already associated with measles-containing vaccines," said the study's lead investigator Nicola Klein, MD, Ph.
Genetic epilepsy with febrile seizures
These alterations often stem from prolonged febrile seizures
, brain infections or trauma.
More serious infections can develop along with measles, including ear infections, sore throat, pneumonia, febrile seizures
, and encephalitis (inflammation of the brain).
A new study in rats, however, indicates that prolonged fever-induced convulsions, or febrile seizures
, cause long-lasting changes in the brain, perhaps rendering it more prone to epilepsy.
An increased incidence of febrile seizures
in patients less than nine years old was associated with the 2010-2011 formulation, which prompted governing panels to recommend against administering Afluria to young children.
Used for febrile seizures
, tonic-clonic seizures, status epilepticus and eclampsia
History of febrile seizures
was noted for 6 (15%) patients.
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures
The authors point out that the previously used, whole-cell pertussis vaccine (DTP) had been associated with an increase in febrile seizures
, but conclude that DTaP is not associated with acute seizure events.
Among these 14 patients, 6 patients had encephalitis; 6 patients, febrile seizures
, and 2 patients, aseptic meningitis.
I think [phenobarbital] should not be used for febrile seizures
," Farwell says.
Administration of CSL's 2010 Southern Hemisphere influenza vaccine was associated with post-marketing reports of increased rates of fever and febrile seizures
in children predominantly below the age of 5 years as compared to previous years; these increased rates were confirmed by post-marketing studies.