Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand
Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand
Interpretation & conclusions: The high levels of sFas antigen and Fas ligand
seen in HIV infected individuals suggest increased activation and apoptosis of T cells, due to constant stimulation of the immune system by inter-current infections of HIV infected individuals in south India.
Dual role for Fas ligand
in the initiation of and recovery from experimental allergic encephalomyelitis.
The structure of TNF-[alpha] is similar to that of the Fas ligand
; consequently, TNF-[alpha] shares some of the functions of Fas ligand
, such as promoting apoptosis.
Recent studies have demonstrated that human colorectal cancer cells show an increase in proapoptotic molecules, for example, Fas and Fas ligand
Recently, oversecretion of interleukin-18 by monocytes in patients with HLH has been described (50); interleukin-18 production may further enhance TNF-[Alpha] and IFN-[Gamma] production by T-lymphocytes and NK cells, as well as induce Fas ligand
expression on lymphocytes, which enhances their cytotoxic effect.
sFas could block apoptosis induced by the Fas ligand
Even then, when these immune cells arrive to instigate the suicide program, their Fas ligand
doesn't work on some cancer cells.
Fas receptor (CD95/APO-1) is a transmembrane protein that triggers apoptosis when stimulated with Fas ligand
Caspase 8 is activated in response to cytokines, including TNF-alpha and Fas ligand
, leading to apoptosis.
The body has a system for regularly ridding itself of unwanted immune cells: When Fas, a protein found on the surface of immune cells, binds to Fas ligand
(FasL), another cell surface protein, the Fas-bearing cell commits suicide.
In a second study, Xiao Ni and colleagues from the MD Anderson Cancer Center in Houston demonstrated that in vitro, bexarotene may inhibit expression of Fas ligand
(FasL, CD95L), a protein involved in regulating apoptosis, or programmed cell death.