Blood coagulation factor Va
abnormality associated with resistance to activated protein C in venous thrombophilia.
important coagulation enzyme, know as Factor Va
, does not return to
Proteolytic inactivation of factor Va
is an important mechanism in limiting clot formation in normal hemostasis.
When this enzyme, know as Factor Va
, does not return to normal levels, clot formation is accelerated.
Company scientists found that certain antibodies derived from patients with Antiphospholipid Syndrome (APS) inhibited the inactivation of clotting Factor Va
, thus potentially increasing the likelihood of inappropriate blood clot formation.
Interestingly, Arg 506 is located at one of the three cleavage sites for APC in factor Va
(Arg 306, Arg 506, and Arg 679).