(redirected from Extrinsic pathway)
Also found in: Dictionary, Medical, Legal, Encyclopedia.
Related to Extrinsic pathway: Prothrombin time, APTT
Graphic Thesaurus  🔍
Display ON
Animation ON
  • noun

Synonyms for coagulation

References in periodicals archive ?
Consequently, the apoptosis mechanism by extrinsic pathways was mediated by Caspase 8 and 9.
Figure 4] also shows the variation of APTT and PT (Biomarkers for intrinsic and extrinsic pathways, respectively) over disease stages in positive DD group.
lucidum exhibited anticoagulative effective in intrinsic but not in extrinsic pathway of blood coagulation while the aqueous extract of S.
The extrinsic pathway is initiated by death receptors, called Tumor Necrosis Factor (TNF).
23) Because the extrinsic pathway is believed to be similar between mammalian and avian species, the much higher relative amount of TF needed could be a result of a higher threshold of activation or, more likely, a weaker compatibility of avian FVII and the human TF used.
The extrinsic pathway is triggered when death ligands bind to their respective cell surface death receptors through recruitment of FAS-associated death domain (FADD) protein, procaspase-8 through the formation of a complex that induces cell death and activation of the caspases (caspase-8 and caspase-10).
The results of these studies also suggest the inhibition of NF-kB activation, the suppression of anti-apoptotic proteins, such as IAP, c-FLIP, Akt kinase, and the initiation of extrinsic pathway of apoptosis by induction of TRAIL and Fas receptor stimulation in cancer cells.
The activation of cell surface death receptors by tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) and death receptor agonists represent an attractive therapeutic strategy to promote apoptosis of tumor cells through the activation of the extrinsic pathway.
This sequence of activation in caspases is broadly classified into two pathways; the extrinsic pathway characterized by involvement of cell surface death receptors and the intrinsic pathway involved in key mitochondrial events.
Cancer cells can escape apoptosis by ignoring signals from the extrinsic pathway or by resetting the balance of intracellular anti- and pro-apoptotic signals, resulting in inhibition of apoptosis [8].
There are 2 major types of hemophilia: hemophilia A (classic hemophilia), which is a functional deficiency of Factor VIII of the intrinsic pathway of coagulation; and hemophilia B (Christmas disease), which is a functional deficiency of Factor IX of the extrinsic pathway of coagulation.
An isolated PT prolongation suggests a deficiency or inhibition of the extrinsic pathway (FVII), but mild factor X, V, and II deficiencies are also possible causes.
The extrinsic pathway is an inducible signaling cascade that is triggered by up-regulation of TF upon inflammation or endothelial injury (Chu 2006).
Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases.