exonuclease

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  • noun

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a nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid

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References in periodicals archive ?
The presence of partially degraded RNA suggests that endonucleases rather than exonucleases are primarily involved in the degradation of salivary RNA, because exonucleases are usually processive, degrading the target RNA substrates completely or giving rise to significant degradation on one end of the mRNA, as has been shown for plasma RNA (26).
The most obvious of these is the nearly immediate degradation of normal phosphodiester-linked nucleotides by the exonucleases abundant both in serum and within cells.
Accordingly, enzymes called exonucleases pick up where UDGases and other base cutters leave off, excising damaged nucleotides.
Cellectis's teams thus succeeded in improving current genome engineering techniques by employing a new approach: co-expressing meganucleases or TALENs[TM], Cellectis's internal technology, together with exonucleases.
Mismatch repair is a complex process that depends on MMR proteins and multiple proteins that interact directly with DNA (single-stranded DNA-binding protein; exonucleases I, VII, and X; RecJ exonuclease; DNA helicase II; DNA polymerase III; and DNA ligase).