Antibody to HHV-6 is typically found in titers of 1:160 and greater in patients with acquired immunodeficiency syndrome, chronic fatigue syndrome, exanthem subitum
, and some lymphoproliferative disorders.
These three herpes viruses, causing mononucleosis, gingivostomatitis, and exanthem subitum
, respectively, remain in a steady state held at bay by cell- mediated immunity.
13,14) Human herpesviruses 6 and 7 infect humans at an early age and cause an erythematous febrile illness, particularly exanthem subitum
complications, including seizures, hemiplegia, meningoencephalitis, or residual encephalopathy, illustrate HHV-6 neurotropism; HHV-6 commonly invades the brain during ES, even in cases of clinically asymptomatic infections.
Primary infection with HHV-6B causes roseola infantum or exanthem subitum
, a common childhood disease that resolves spontaneously.