Lot 2 short-acting erythropoietins in nephrology bail (5% of the original amount of the property (excluding VAT), rounded to the next ten.
Lot 3 Short-acting erythropoietins in oncology bail (5% of the original amount of the property (excluding VAT), rounded to the next ten.
GROWTH FACTORS - AN OVERVIEW II-26 Blood Growth Factors II-26 Erythropoietins
II-26 Types of Erythropoietins
II-27 Epoetin II-27 Darbepoetin II-27 Aranesp II-27 Aranesp Vs.
PHILADELPHIA -- Treatment with a specific brand of recombinant human erythropoietin
, Eprex, has been strongly linked to 96 cases of pure red cell aplasia in a review by the drug's manufacturer, Johnson & Johnson.
is a hormone produced by healthy kidneys that stimulates red blood cell (RBC) production.
Comparative study of the asparagine-linked sugar chains of human erythropoietins
purified from urine and the cell culture medium of recombinant Chinese hamster ovary cells.
Table 2: World Market for Erythropoietins
(2000-2010): Geographic Regions Ranked by CAGR - Europe, US, Japan and Rest of World (includes corresponding Graph/Chart) II-14 Colony Stimulating Factors II-14 Granulocyte-Colony Stimulating Factor II-14 Granulocyte Macrophage-Colony Stimulating Factor II-14 Other Colony Stimulating Factors II-14 Macrophage Colony Stimulating Factor (M-CSF) II-15 Key Functions of M-CSF II-15 Side-Effects of Colony-Stimulating Factors II-15
Table 24: World 15-Year Perspective for Erythropoietins
Table 8: World Historic Review for Blood Growth Factors byType - Erythropoietins
, Colony Stimulating Factors,Interferons and Interleukins Markets Independently Analyzedwith Annual Sales Figures in US$ Million for Years 2003through 2008 (includes corresponding Graph/Chart) II-67
treatment of renal-disease-related anemia represents over 70% of these costs, followed by vitamin D treatment of secondary hyperparathyroidism.
Amgen revolutionized anemia treatment with the development of recombinant erythropoietin
, Epoetin alfa.
Aranesp is the most commonly prescribed erythropoietic treatment for anemia in the EU, and is the first and only erythropoietin
approved for every three or four week dosing," said Beth Seidenberg, senior vice president of development and chief medical officer at Amgen.
Physiological stimuli for erythropoietin
Patients with CKD often suffer from serious complications such as anemia, which occurs when failing kidneys no longer produce sufficient erythropoietin
, a hormone that stimulates the production of oxygen-carrying red blood cells (RBCs).
In the group who had no previous treatment with an erythropoietin
(n=57), 77 percent of patients had an erythroid response with 47 percent classified as major (greater than or equal to 2 g/dL increase from baseline hemoglobin or transfusion independence).