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The company is also planning a study of progression-free survival and other outcomes, including overall survival and thrombotic events, in anemic women who are receiving first-line chemotherapy for metastatic breast cancer; they will be randomized to receive Eprex or placebo, with a target hemoglobin of 12 g/dL.
Aranesp [R] and Eprex [R] should not be increased by more than 30% increments at any given time, whereas dose decreases may be more than 30% increments
J&J reported the week prior that early data showed Eprex patients in the German study died more frequently than placebo patients, and said it was doing additional analyses to better understand the findings.
PHILADELPHIA -- Treatment with a specific brand of recombinant human erythropoietin, Eprex, has been strongly linked to 96 cases of pure red cell aplasia in a review by the drug's manufacturer, Johnson & Johnson.
European regulators might ban the use of Eprex because it has been associated with a rare but serious side effect.
According to surveyed German nephrologists, the majority of their epoetin alfa-treated patients receive a biosimilar, whereas their French counterparts indicate that they prescribe the reference brand, Johnson & Johnson's Eprex, to a greater proportion of patients than biosimilars.
Novartis AG's Sandoz unit, the world's second-largest maker of generic drugs, became the first company to win approval for a biological copy of Johnson & Johnson's (New Brunswick NJ) Eprex anemia treatment, allowing it to offer cheaper versions to Europeans.
Eprex and Procrit, both marketed by Johnson & Johnson, also treat anemia.
Its most prominent brands include Remicade, Procrit (or Eprex outside of the US), Levaquin, Risperdal Consta, Concerta, Aciphex/Pariet, Duragesic (or Durogesic outside of the US), Velcade, Prezista and Invega.
A new Sanyo Scientific Biomedical medication fridge that is connected to the clinic's security system has been purchased for Eprex and Aranesp.
Eprex and Procrit, which have completely different structures under a microscope than Aranesp, are also used to treat anemia.
The Ortho Biologics plant in Manati manufactures the anemia drug Eprex, which has been linked to serious illnesses in Europe and Canada.
Inservice given on the new syringes for Eprex (safety syringes).
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