They are characterized by epithelioid cells
with clear to eosinophilic cytoplasm and are often arranged around delicate fibrous septa and blood vessels.
Nevus of large spindle and/or epithelioid cells
Epithelioid AML, the second group of renal AMLs, are composed of sheets of epithelioid cells
that can behave aggressively, with the potential for metastasis and resultant adjuvant therapy.
This unusual pattern of spindled and epithelioid cells
caused diagnostic difficulty largely because it was the predominant histologic pattern in the splenic tumor and this pattern had not been noted in the primary ovarian and peritoneal tumors.
In some areas, epithelioid cells
with moderate amounts of eosinophilic cytoplasm were seen as a minor component (figure 2, C).
Pathology revealed subtotal replacement by a metastatic tumor composed of epithelioid cells
resembling the original gastric tumor cells (Fig.
Cytoplasmic organelles were not well preserved, but both the spindle and vacuolated epithelioid cells
revealed scattered, moderately dense, moderately pleomorphic intracellular granules.
These epithelioid cells
secrete more than 40 cytokines and mediators, including angiotensin-converting enzyme (ACE).
There were many ganglion-like cells, spindle cells and epithelioid cells
in the lesion.
Less frequently, the epithelioid cells
were associated with prominent cytoplasmic vacuolization, suggesting mucin production and/or glandular differentiation.
Histopathology of the parotid mass revealed that it was made up of a group of lymph nodes whose architecture was preserved; the mass contained a proliferation of histiocytes, hyperplastic follicles, enlarged germinal centers, and epithelioid cells
with abundant, pale eosinophilic cytoplasm (figure 2).
Round cells are small epithelioid cells
distributed within the interstitium and are characterized by well-defined cell borders, fine chromatin, and inconspicuous nucleoli.
7] E-AML tumours are comprised of round to polygonal epithelioid cells
with clear or granular eosinophilic cytoplasm intermixed with spindle cells, often showing varying degress of mitotic activity.
Histology of the deep biopsy specimen identified features of granulomatous inflammation and palisading epithelioid cells
, Langhans' giant cells, lymphocytes, and a few neutrophils with small foci of caseous necrosis (figure 1).
Observation of 3 signals is sufficient because signals off the plane of section are often not visualized, particularly in large, spitzoid or epithelioid cells