Highly sensitive and specific HPLC with fluorometric detection for determination of plasma epinephrine and norepinephrine applied to kinetic studies in humans.
For initial examination of tumor catecholamine phenotypes, designations of epinephrine-producing (adrenergic) and predominantly norepinephrine-producing (noradrenergic) tumors were based on tissue epinephrine content as a percentage of both epinephrine and norepinephrine, according to previous observations in two groups of patients with differing production of phenylethanolamine-N-methyltransferase, the enzyme that converts norepinephrine to epinephrine (11,12).
Overworking it leads to higher blood pressure and an increased heart rate by pumping too much epinephrine and norepinephrine into the blood, constricting the blood vessels.