The scientists found that neighbouring "epithelial-like" ependymal cells
- not stem cells themselves - maintain a special structure that keeps neural stem cells "neurogenic," able to make new neurons.
The lateral ventricular wall consists of four layers with various thicknesses and cell densities: a monolayer of ependymal cells
(layer I), a hypocellular gap containing astrocytic processes (layer II), a ribbon of cells composed of astrocytes (layer III), and a transitional zone into the brain parenchyma (layer IV) (9).
The injection of purified Ad-vectors into the lateral ventricles of adult mice leads to the transduction of ependymal cells
aligning the lateral ventricles (Fig.
In the brain, the ventricular surfaces and aqueducts are lined by ciliated ependymal cells
which form a barrier between the infected CSF of patients with meningitis and the neuronal tissue.
AMP deaminase in rat brain: localization in neurons and ependymal cells
Immunohistologic analysis confirmed systemic infection and revealed influenza virus nucleocapsid protein in 1) ganglions of the adrenal medulla, 2) ependymal cells
of the central nervous system (associated with marked lymphocytic meningitis and perivascular cuffing), 3) thymus epithelia, and 4) epithelia of the exocrine pancreas (Figure 1).
These lesions are thought to arise from subependymal glial cells, although other considerations include astrocytes from the subependymal plate, ependymal cells
, and mixed ependymal and astrocytic cells (2, 5).
These tumors arise from the ependymal cells
of the central canal; hence, they are located centrally, as opposed to the eccentric location of astrocytomas (Table 2).
Occasionally, ependymal cells
of the spinal cord were also positive.