The finding that FluCide drug candidates showed substantially reduced extent of white blood cells, and in particular, eosinophils
, in the lung tissue, is very significant," said Randall W.
In the study, the three highest doses of dupilumab in combination with standard-of-care therapy met the primary endpoint of a statistically significant improvement from baseline in forced expiratory volume over one second (FEV1, a standard measure of lung function) at Week 12 in patients with high blood eosinophils
(greater than or equal to 300 cells/microliter), as compared to placebo in combination with standard-of-care therapy.
3,4) In affected patients, eosinophils
and other inflammatory cells are released from the bone marrow under the influence of several Th2 cytokines, including interleukin 3 (IL-3), IL-4, IL-5, IL-13, IL-17, and eotaxin.
We are proud that our work in this area, to better understand the specific role eosinophils
play in severe asthma, has resulted in the licensing of mepolizumab as the first anti-IL-5 biological treatment.
and showed that adult and adolescent asthma patients with elevated blood eosinophils
, whose symptoms were inadequately controlled with inhaled corticosteroid-based therapies, experienced reduced asthma exacerbation rates and significantly improved lung function, quality of life and other secondary measures of asthma control with reslizumab as add-on therapy, versus placebo.
These polyps are infiltrated by a variety of immunologic cells; eosinophils
, neutrophils, plasma cells, mast cells, macrophages, lymphocytes, and their subgroups have all been found in nasal polyps.
The American Partnership for Eosinophilic Disorders (APFED) will celebrate the 7th annual National Eosinophil
Awareness Week May 18- May 24 by uniting patients, families, patient advocacy groups, medical institutions, medical societies, physicians, and companies that support those who have eosinophil
-associated diseases in effort to create awareness and educate the public and the medical community about these diseases.
These molecules enable eosinophils
to congregate in airways where they cause allergic inflammation.
Liver biopsy revealed eosinophilic microabscesses and Charcot-Leyden crystals formed by the breakdown of eosinophils
Idiopathic hypereosinophilic syndromes (HESs) are rare disorders that comprise a heterogeneous group of diseases characterized by unexplained persistent, nonreactive overproduction of eosinophils
The DIFF scattergram from the XE2100 analyser contained a large grey-out area where the population of eosinophils
normally locates (Figure 1).
Diagnosis of EoE is determined only by symptoms of oesophageal dysfunction in conjunction with positive oesophageal biopsies (a minimum of 15-24 eosinophils
per high-power field), as individually either could be indicative of other disease processes (Enns 2010).
It is our understanding that the calibrated value of the instruments with five different settings is more exact than any other manual method used to count eosinophils
Moreover, 64% of all subjects achieved a reduction to the target level of 5 or fewer eosinophils
per high-powered field.
Corticosteroid medications for asthma target eosinophils
, a type of white blood cell that produces inflammation in the respiratory tract.