References in periodicals archive ?
Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners.
Hepatic enzyme induction and acute endocrine effects of 2,2',3,3',4,6'-hexachlorobiphenyl and 2,2',3,4',5',6-hexachlorobiphenyl in prepubertal female rats.
Biomarkers of exposure versus biomarkers of hepatic enzyme induction.
Our hypothesis was that biomarkers of hepatic enzyme induction would be increased as a result of the chronic exposure to OCs in this fish-eating population.
Beside studies to investigate direct and acute effects of green tea and its constituents on cellular systems also experiments were done to elucidate the role of green tea in regulation of gene expression and enzyme induction (Embola et al.
The higher amount of dioxin-like PCBs present in lot 6024 gave rise to greater enzyme induction as measured by EROD and MROD.
Enzyme induction is a common biological mechanism to increase total enzymatic activity.
Attendees will hear information regarding drug metabolism, enzyme inhibition, in-vitro toxicity, enzyme induction, in-vitro/in-vivo correlations, transporters and regulatory issues in a dynamic forum with comprehensive panel discussions.
Thus they may save years of time and millions of dollars during preclinical drug discovery, development and testing stages, eliminating the problem of supply and variability that restrict the use of harvested human liver cells for enzyme induction, cellular toxicity assays and other in vitro screening.
Thus they may save pharmaceutical companies years of time and millions of dollars during preclinical development and testing stages, because they can help solve the problem of supply and variability that restrict the use of harvested human liver cells for enzyme induction, cellular toxicity assays and other in vitro screening.
A key reason is that they can help solve the problem of supply and variability that restrict the use of harvested human liver cells for enzyme induction, cellular toxicity assays and other in vitro screening.
MultiCells's human hepatocyte lines can help solve the problem of supply and variability that restrict the use of harvested human liver cells for enzyme induction, cellular toxicity assays and other in vitro screening.
His presentation will compare fresh and cryopreserved human hepatocytes to MultiCell's human hepatocyte cell line that has the potential to solve the problem of supply and variability that restrict the use of human hepatocytes for enzyme induction and other in vitro screening.
founder, president and CEO of Exten's marketing partner, XenoTech LLC, presented "Immortalized Hepatocytes: A New In Vitro Approach to Early Induction and Hepatotoxicity" in which he discussed MultiCell's new immortalized human hepatocyte line, which has the potential to solve the serious problem of supply and variability that restrict the use of human hepatocytes for in vitro studies including enzyme induction.
Her responsibilities included the design of protocols for special studies on the metabolism of test chemicals, their effects on immune competence, enzyme induction and hormone levels.