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  • noun

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a substance (an atom or molecule or radical or ion) that forms a complex around a central atom

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Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.
The predominance of phytoestrogens as potent agents for ER and NodD signaling further supports the theory that an evolutionarily ancient or ancestral ER may have recognized and responded to phytoestrogens even before the emergence of the natural endogenous ligand [E.
The novel concept of developing allosteric modulators acting on a regulatory site rather than on the endogenous ligand site provides a meaningful way of enhancing the potency of the endogenous ligand and developing compounds with higher specificity and efficacy.
In addition, transforming growth factor (alpha)"TGF-(alpha)" the endogenous ligand for the EGFR, was also repressed.
The scientific abstract entitled "Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance" is available in the current edition of the journal or on-line at http://www.
The discovery of cannabinoid receptors and an endogenous ligand, arachidonoyl ethanolamide, has renewed interest in finding nonpsychoactive derivatives of cannabinoids with medicinal properties.
Although the endogenous ligand for the unknown receptor has been previously identified, to date the corresponding endogenous receptor has not been discovered.
Any new GPCR can be inserted into SNAP UFA(TM) and an endogenous ligand determined in as little as four weeks.
Using a test set of 36 GPCRs for which the endogenous ligand is already known, 91% of these GPCRs can be detected using the UFA technology.
In addition to its endogenous ligands, N,N- dimethyltryptamine (DMT) and the ER chaperone BIP, the sigma receptor binds a wide range of exogenous ligands and therapeutic compounds.
The Endocannabinoid System mainly comprises two receptors (CB1 and CB2), two endogenous ligands and two metabolism enzymes.
The mechanisms implicated in the interactions between opioids and cannabinoids involve several components of these systems, including alteration of the levels of endogenous ligands as well as their respective receptors.
TLRs have also been shown to recognize endogenous ligands in autoimmune diseases.
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