During TACT, 1,708 heart attack patients were randomized to receive 40 infusions of a 500 mL edetate
disodium-based chelation solution or a placebo infusion, with a second randomization to an oral vitamin and mineral regimen or an oral placebo.
It is also combined with edetate
calcium disodium for lead poisoning.
The FDA alleged that Evers had violated the Federal Food, Drug, and Cosmetic Act (the Act) under misbranding provision by promoting and administering a chelating drug, calcium disodium edetate
(calcium EDTA), an FDA-approved drug for an indication not approved by the agency.
The sodium edetate
preferentially forms more stable complexes with polyvalent cations (e.
Although we propose that a primary magnesium deficiency was the reason for the lack of response to calcium and cholecalciferol supplementation, other treatments that were administered, such as edetate
calcium disodium (Ca[Na.
Excipients: Lecithin, triglycerides, polysorbate 80, propylene glycol, carbomer 980, sodium hydroxide, disodium edetate
, purified water, benzoic acid (E210).
Although there are only a limited number of such products, one example is Blink-N-Clean (Abbott Medical Optics Inc, Santa Ana, California, USA), which contains the surfactant Tyloxapol and edetate
disodium as a chelating agent.
Inactive ingredients: edetate
disodium, polysorbate 80, lactose anhydrous, sodium hydroxide and/or hydrochloric acid (for pH adjustment).
The only effective test used for bone lead levels is the disodium edetate
(EDTA) chelating agent test.
Among the new entries are aluminum hydroxide adjuvant, disodium edetate
, ethyl lactate, hectorite, lactose spray dried, lauric acid, linoleic acid, raffinose, and saponite.
Combined therapeutic potential of meso-2,3-dimercaptosuccinic acid and calcium disodium edetate
on the mobilization and distribution of lead in experimental lead intoxication in rats.
2] Another similar study used a formulation consisting of apomorphine, sodium metabisulphite, and sodium edetate