11) These views were supported by studies which showed that even those EPEC strains which had been associated with outbreaks of diarrhoea and had caused diarrhoea in volunteers lacked known virulence determinants, causing some investigators to suggest that these strains were in fact ETEC or EIEC
which had lost the capacity to produce enterotoxins or invade epithelial cells during storage.
Mr Hey said although the EIEC
letter may not be illegal, it preyed on many companies' anxieties following the registering of new devices.
coli strains (ETEC, EHEC, EIEC
, and EAEC) associated with human illness from 24.
coli strains from 430 patients were selected, and all were analyzed by a multiplex PCR (3) that detects the following pathogenic genes: heat-stable and heat-labile enterotoxins (st, lt) for ETEC, intimin (eaeA) and bundle-forming pilus (bfp) for EPEC, Shiga toxin 1 and 2 (stx1, stx2) and intimin (eaeA) for STEC, and invasion-associated loci (ia1) for EIEC
coli were also screened by PCR for the same molecular marker used for EIEC