Even if we had an intervention that led to everybody being fully adherent, we would still see the evolution of drug resistance
," he said.
drug mechanisms not previously developed in any previous drug development phase), representing 157, 56, 84 and 37 new drug classes at preclinical, phase I, phase II and phase III, respectively iv) Strategies to Combat Cancer Drug Resistance
: including targeting, bypassing or exploiting resistance mechanisms, current and new drug combinations and novel drugs offering new ways to target drug resistance
In this case, we use samples of TB genotypes, together with information about drug resistance
, to make inferences and predictions that wouldn't have been possible just a few years ago.
It is likely there are outbreaks of drug resistance
going unnoticed and undetected.
Low rates of initial drug resistance
have been reported in countries in which the DOTS strategy has been successfully implemented.
He focused his effort on the study of HIV-1 fitness and its relationship with drug resistance
and disease progression, developing novel systems to quantify HIV-1 replicative fitness.
The drivers of the drug resistance
problem include: over-the-counter sales in developing countries, inappropriate patient demand in industrial countries, and lack of incentives for new drug and diagnostics development.
In this study, HIV-infected patients failing their current therapies due to drug resistance
are treated with bevirimat (12 patients) or placebo (4 patients) on top of their failing background drug regimen for 14 days, a period of "functional monotherapy.
Since clinical data were not available, only combined (primary plus acquired) drug resistance
rates were analyzed.
CANCELLED: 4th European Symposium on the Clinical Implications of HIV Drug Resistance
, had been scheduled for April 5-7, in Frankfurt, Germany http://www.
announced today that the first national assessment of HIV drug resistance
has revealed that 78 percent of HIV patients with measurable levels of virus in their blood are infected with an HIV strain that is resistant to one or more AIDS drugs.
Such drug resistance
frequently causes chemotherapy to fail, says Scheper.
The molecularly targeted drugs - imatinib and nilotinib (Novartis), and dasatinib (Bristol-Myers Squibb) - inhibit the Bcr-Abl protein and are important therapies for patients with CML; however, treatment with these drugs results in mutations of the Bcr-Abl gene, which create substantial drug resistance
Observed declines in drug resistance
to nucleoside reverse transcriptase inhibitors among persons recently infected with HIV-1 in monitored subpopulations can be interpreted as a positive sign and lead public health officials to decrease efforts towards HIV prevention.
3) Partial restoration of drug-sensitive ("wild-type") virus--For individuals who have taken many HIV medications and developed drug resistance
, some investigators have suggested that an interruption in treatment could once again make the virus "drug sensitive.